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2006-9 Traficet – ChemoCentryx (Kendle) Protocol CL004_282 A Multinational Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of CCX282-B in Subjects with Moderate to Severe Crohn’s Disease 2004-6 CDP – Celltech (ICON) Precise 1: Protocol CDP870-031 - A Phase III multi-national, multi-centre, double-blind placebo-controlled parallel group, 26 week study to assess the safety and efficacy of the humanised anti-TNF PEG conjugate, CDP870 400 mg sc, (dosed at Weeks 0, 2, 4 then 4-weekly to Week 24), in the treatment of patients with active Crohn's Disease Precise 3: Protocol CDP870-033 A Phase III multi-national, multi-centre, open-label, 52 week safety study to assess the safety of chronic therapy with the humanised anti-TNF PEG conjugate, CDP870 400 mg sc, (dosed 4-weekly to Week 50), in the treatment of patients with active Crohn's Disease who have previously completed studies CDP870-031 or CDP870-032 Precise 4: Protocol CDP870-034 - A Phase III multi-national, multi-centre, open label, 52 week safety study to assess the safety of re-exposure after a variable interval and subsequent chronic therapy with the humanised anti-TNF PEG conjugate, CDP870 400 mg sc, (dosed at Weeks 0, 2, 4 then 4-weekly to Week 48), in the treatment of patients with active Crohn's Disease who have previously been withdrawn from studies CDP870-031 or CDP870-032 2005-6 Leukine – Schering (Schering/Novotech) Protocol 308380 Phase 3 Randomized, Double-Blind, Placebo Controlled Induction Study of Sargramostim (Leukine) in Patients with Active Crohn’s Disease 2005-6 Leukine – Schering (Schering/Novotech) Protocol 307340 Open-label Trial of Leukine (Sargramostim), A Recombinant Human Granolocyte-Macrophage Colony Stimulating Factor (GM-CSF), in Active Crohn’s Disease 2008 TSO – Asphelia (Novotech) Protocol Number ASP1002-CD-201 A randomised, double-blind, placebo-controlled trial of ASP1002 ( Trichuris suis ova [TSO]) therapy for moderately active Crohn's Disease.
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SIZE:120 Capsules
Another potential limitation is that the trials were not designed to evaluate whether untreated tick-borne coinfections influenced outcomes
